IL22RA&IL10RB BaF3
CBP74644
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| I. Background | |
| IL22RA1(IL-22受体α1链)与IL10RB(IL-10受体β链)共同组成IL-22的功能性异二聚体受体复合物。IL-22与该复合物结合后,主要激活JAK-STAT信号通路(尤其是STAT3),同时也激活MAPK/ERK和PI3K-AKT通路。该信号轴在上皮细胞的增殖、存活、抗炎细胞因子分泌以及黏膜免疫和组织修复中发挥关键作用。此外,IL10RB是一个共享的信号转导亚基,除IL-22外,它也参与组成IL-10、IL-26、IL-28和IFN-λ等细胞因子的受体复合物。 | |
| II. Description | |
| N/A | |
| III. Introduction | |
| Expressed gene: | IL22RA&IL10RB |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640+10%FBS + 200ng/ml IL22 +2 μg/ml Puromycin+ 5 μg/ml Blasticidin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Anti-prolieration Assay |
| IV. Representative Data | |
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